Written by Emily K. Willis, Lead Editor | Updated on the 17th of August 2023
Medically reviewed by Dr. Sarah D.Ferguson, MD
The body's largest organ, the skin, is a part of the integumentary system (the body’s outer layer), which guards the body against various types of harm. It shields us from environmental elements such as UV rays, chemicals, and even microbes.
Figure: Layers and structures of the skin
Even though the skin has many layers, it is usually made up of three main parts, and aging affects all three layers of the skin, as well as the connective tissue in each layer that contains collagen and elastin.
Epidermis- The epidermis is the water-resistant outer layer of skin and the body’s first line of defense against ultraviolet radiation, bacteria, and other invading pathogens. With aging, the epidermis becomes thinner, making the skin more translucent, paler, and more susceptible to damage like sunspots.
Dermis- Collagen and elastin are found in the dermis. After the age of 20, 1% less collagen is produced in the dermis each year. The collagen and elastin fibers become increasingly clumped and loose. This makes the skin less flexible, which results in wrinkles and sagging skin.
Hypodermis- The hypodermis shields the skeletal system, organs, muscles, and tissues from harm. As we age, the loss of fat below the skin in the cheeks, temples, chin, nose, and eye area may result in the loosening of the skin, sunken eyes, and a "skeletal" appearance.
Several factors are responsible for aging but here are some of the main categories:
Figure: Mean score for wrinkles in various age classes
The skin naturally becomes less elastic and more delicate as we age. With time, fat in the deeper layers of the skin and natural oil production is gradually reduced, which dries out the face and accentuates wrinkles.
(ii.) Photoaging (sun damage)
Figure: UV penetration into the layers of the skin
Exposure to UV light accelerates the breakdown of the skin's connective tissue (collagen and elastin fibers), which lies in the deeper layer of the skin (dermis). Without supportive connective tissues, the skin loses its strength and flexibility, causing it to sag and wrinkle prematurely.
Figure: Psychological stress deteriorates skin barrier function
Cortisol, a stress hormone, is produced in excess by our bodies under stressful conditions, which speeds up the process of DNA damage and contributes to premature skin aging.
(iv.) Facial Movements
Figure: Persistent wrinkles are visible even without expression
Repetitive facial movements such as squinting, frowning, and smiling form wrinkles. That is why modern cosmetic treatments such as Botox work on preventing nerves to contract wrinkle-forming muscles.
Figure: Collagen bonds with toxic sugar
A diet high in sugars and carbs can lead to premature skin aging. Sugars cause inflammation and produce damaging free radicals that accelerate the breakdown of the skin’s structural components.
For thousands of years, snake venoms have been used in traditional medicines to treat smallpox and to heal wounds. As a snake bite usually results in paralyzed muscles in the affected area, the benefits of snake venom’s neuromuscular activity reaction were noted by scientists, especially in the area of cosmetics.
So, scientists teamed up to synthetically manufacture peptides that are similar in structure to naturally occurring snake venom by taking a protein from the Temple Viper’s venom known as tri-peptide Walglerin 1 with the aim to reduce muscle contractions that result in expression lines on our faces that eventually form wrinkles.
Without any invasive anti-aging procedures, this synthetic version of snake venoms works like Botox to temporarily relax the muscles in the face by up to 80% (in-vitro results), preventing the formation of new wrinkles and improving the condition of the existing ones.
Due to the reduction in micro-contractions, a significant smoothing effect can already be noticed after 14 days.
In a 14-day trial on 75 volunteers, those that used it claimed that wrinkle size was reduced by up to 68% after applying the synthetic snake venom twice daily.
Figure: Synthesized snake venom serums have significantly decreased expression lines on the forehead
Meet Karen J. Smith, a successful 35-year-old executive who spends most of her days in front of a computer screen. She had dedicated her life to her career. She loved her job, but the long hours and constant stress had taken a toll on her skin. Karen had always prided herself on her appearance, but lately, she noticed that her skin was dull, dehydrated, and prone to breakouts. Karen had tried various skincare products, but nothing seemed to work. She was feeling frustrated and insecure about her appearance, and it was starting to affect her confidence in her professional and personal life. That's when her colleague recommended the snake venom peptide serum.
Within three days after applying the serum every day and night, Karen noticed a significant difference in her skin's texture and appearance. The serum absorbed quickly into her skin, leaving it feeling smooth. As she touched her face, she felt the serum's velvety texture sinking into her skin. She also noticed that her skin looked brighter and more radiant. Karen couldn't believe her eyes when she looked in the mirror, she felt relieved to finally see herself again without the fine lines of aging.
Karen's colleagues started complimenting her on her skin's transformation by day 10. She no longer had any breakouts, and her complexion was glowing. The fine lines around her eyes had softened, and her skin felt firmer and more hydrated. Karen couldn't believe how much of a difference the serum had made in such a short amount of time. Her skin looked even more flawless, and she felt like she was glowing from within.
By day fourteen, Karen's skin looked even more incredible. Her skin was now brighter, smoother, and more even-toned than it had ever been. The serum had also helped to reduce the appearance of her pores, which had always been a concern for her. Karen was thrilled with the results and couldn't stop smiling every time she looked in the mirror. She felt more comfortable and confident in her own skin, and her newfound radiance had boosted her self-esteem in all aspects of her life. She even became known as the beautiful girl boss in their company.
“I had been feeling so down about my appearance, especially when I looked at the deep creases on my forehead, under my eyes, and around my mouth. I couldn't help but feel insecure about how I looked. But snake venom peptide serum changed everything. Within days, the lines on my face began to fade, and even my neck area, which was once sagging, was now lifted! I can now step out of the house without feeling the need to put on layers of makeup or cover my face with huge sunglasses to hide my insecurities. It feels empowering to know that my skin looks better than it has in years, and I don't have to hide behind anything anymore. My family and friends won't stop complimenting how good I look. Some have even asked if I had plastic surgery! I feel like I've regained a part of myself that I had lost.”
-Karen J. Smith, 35, Satisfied User